研究業績

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2024.3.21

The health history of first-degree relatives’ dyslipidemia can affect preferences and intentions following the return of genomic results for monogenic familial hypercholesterolemia
第一度近親者に脂質異常症の病歴があると、家族性高コレステロール血症の遺伝情報回付後にその結果に関する好みや意向へ影響を及ぼす可能性がある

Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Kayono Yamamoto, Yasushi Ishigaki, Hiroshi Kawame, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Akira Uruno, Kichiya Suzuki, Kozo Tanno, Hideki Ohmomo, Atsushi Shimizu, Masayuki Yamamoto and Makoto Sasaki

[Genes][概要icon-pdf PDF]

 

2023.12.28

Stakeholder perception of the implementation of genetic risk testing for twelve multifactorial diseases
12多因子疾患の遺伝学的リスク検査実施に関するステークホルダの認識

Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Fuji Nagami, Yuko Minoura and Makoto Sasaki

[Genes][概要icon-pdf PDF]

 

2023.9.21

Association between vascular endothelial dysfunction and stroke incidence in the general Japanese population: results from the Tohoku medical megabank community-based cohort study
日本人における血管内皮障害と脳卒中発症の関連

Harutomo Numazaki, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Koichi Asahi, Hideki Ohmomo, Atsushi Shimizu, Shinichi Omama, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki

[International Journal of Cardiology Cardiovascular Risk and Prevention][概要icon-pdf PDF]

 

2023.3.28

Japanese Translation and Validation of Genomic Knowledge Measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK)
iGLAS-GK(遺伝リテラシーと態度に関する国際調査におけるゲノム知識尺度)の日本語版作成と尺度の検証

Akiko Yoshida, Tomoharu Tokutomi, Akimune Fukushima, Robert Chapman,Fatos Selita, Yulia Kovas, Makoto Sasaki

[Genes][概要 icon-pdf PDF]

 

2023.2.17

Association between the extent of house collapse and urine sodium-to-potassium ratio of victims affected by the 2011 Great East Japan Earthquake and Tsunami: a cross-sectional study
東日本大震災被災者における家屋崩壊の程度と尿中Na/K比との関連について

Takahiro Mikami, Kozo Tanno, Ryohei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Koichi Asahi, Fumitaka Tanaka, Shinichi Omama, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Atsushi Hozawa, Jiro Hitomi, Kiyomi Sakata, Makoto Sasaki

[Hypertension Research][概要 icon-pdf PDF]

 

2022.11.1

Association between Plasma Xanthine Oxidoreductase Activity and the Renal Function in a General Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study
日本人におけるキサンチン酸化還元酵素と腎機能との関連

Satoru Taguchi, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Fumitaka Tanaka, Koichi Asahi, Hideki Ohmomo, Hiroto Kikuchi, Takamasa Kobayashi, Yoshihiro Morino, Atsushi Shimizu, Kenji Sobue, Makoto Sasaki

[Kidney and Blood Pressure Research][概要 icon-pdf PDF]

 

2022.9.28

Association between high-sensitivity cardiac troponin T levels and incident stroke in the elderly Japanese population: Results from the Tohoku Medical Megabank Community-based Cohort Study
日本高齢者における高感度トロポニンTと脳卒中発症の関連

Takamasa Kobayashi, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Koichi Asahi, Hideki Ohmomo, Atsushi Shimizu, Shinichi Omama, Hiroto Kikuchi , Satoru Taguchi, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki

[American Journal of Cardiology][概要 icon-pdf PDF]

 

2022.6.9

Evaluation of short-term epigenetic age fluctuation
エピゲノム年齢の短期変動評価

Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Shiori Minabe, Akira Takashima, Kozo Tanno, Makoto Sasaki ,and Atsushi Shimizu

[Clinical Epigenetics][概要 icon-pdf PDF]

 

2022.5.20

Association between total type I collagen N-terminal propeptide and coronary artery disease risk score in the general Japanese population
日本人におけるⅠ型プロコラーゲン-N-プロペプチドと冠動脈疾患リスクの関連

Hiroto Kikuchi, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Koichi Asahi, Hideki Ohmomo, Takamasa Kobayashi, Satoru Taguchi, Yoshihiro Morino, Atsushi Shimizu, Kenji Sobue, Makoto Sasaki,

[International Journal of Cardiology Heart & Vasculature][概要 icon-pdf PDF]

 

2022.4.5

Association between Social Isolation and Total Mortality after the Great East Japan Earthquake in Iwate Prefecture: Findings from the TMM CommCohort Study
東日本大震災後の社会的孤立感と死亡との関連:TMM CommCohort Studyからの知見

Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Kotaro Otsuka, Ryohei Sasaki, Nobuyuki Takanashi, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki

[International Journal of Environmental Research and Public Health]
[概要 icon-pdf PDF]

 

2021.12.22

Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics
臨床における実用的な指標としてのDNAメチル化変動

Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka‑Yamasaki, Kozo Tanno, Makoto Sasaki ,and Atsushi Shimizu

[Clinical Epigenetics][概要 icon-pdf PDF]

 

2021.12.8

Low MICA gene expression confers an increased risk of Graves’ disease: a Mendelian randomization study
バセドウ病リスク上昇にMICA遺伝子の低発現が関わる―メンデル無作為化解析結果―

Yoichi Sutoh, Shohei Komaki, Taiki Yamaji, Shiori Suzuki, Ryoko Katagiri, Norie Sawada, Kanako Ono, Hideki Ohmomo, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Akira Takashima, So Umekage, Motoki Iwasaki, and Atsushi Shimizu

[Thyroid][概要 icon-pdf PDF]

 

2021.5.15

Association between the social isolation and depressive symptoms after the Great East Japan Earthquake: Findings from the baseline survey of the TMM CommCohort Study
東日本大震災後の社会的孤立感と抑うつ症状との関連性:TMM CommCohort Studyのベースライン調査からの知見

Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Eri Takusari,Kotaro Otsuka, Hiroaki Tomita, Ryohei Sasaki, Nobuyuki Takanashi, Takahiro Mikami, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yasuyuki Taki, Atsushi Shimizu, Jiro Hitomi, Mamoru Satoh, Makoto Sasaki

[BMC Public Health][概要 icon-pdf PDF]

 

2021.2.16

Plasma xanthine oxidoreductase activity is associated with a high risk of cardiovascular disease in a general Japanese population
血漿中キサンチン酸化還元酵素活性は日本人一般集団における心血管疾患の高リスクと関連している

Yuka Kotozaki, Mamoru Satoh, Kozo Tanno, Hideki Ohmomo, Ryo Otomo, Fumitaka Tanaka, Takahito Nasu, Satoru Taguchi, Hiroto Kikuchi, Takamasa Kobayashi, Atsushi Shimizu, Kiyomi Sakata, Jiro Hitomi, Kenji Sobue, Makoto Sasaki

[International Journal of Environmental Research and Public Health]
[概要 icon-pdf PDF]

 

2020.12.18

Evaluation of clinical formalin-fixed paraffin-embedded tissue quality for targeted-bisulfite sequencing
ターゲットバイサルファイトシークエンシング法のための臨床ホルマリン固定パラフィン包埋組織の品質評価

Hideki Ohmomo, Shohei Komaki, Kanako Ono, Yoichi Sutoh, Tsuyoshi Hachiya, Eri Arai, Hiroyuki Fujimoto, Teruhiko Yoshida, Yae Kanai, Makoto Sasaki, Atsushi Shimizu

[Pathology International][概要 icon-pdf PDF]

 

2020.12.13

A genome-wide association study for highly sensitive cardiac troponin T levels identified a novel genetic variation near a RBAK-ZNF890P locus in the Japanese general population
日本人でのゲノムワイド関連解析による高感度トロポニンTに関連する感受性遺伝子の網羅的解析

Takahito Nasu, Mamoru Satoh, Tsuyoshi Hachiya, Yoichi Sutoh, Hideki Ohmomo, Sho Hitom, Satoru Taguchi, Hiroto Kikuchi, Takamasa Kobayashi, Yuji Takahashi, Takuya Osaki, Yoshihiro Morino, Atsushi Shimizu, Kenji Sobue, Makoto Sasaki

[International Journal of Cardiology][概要 icon-pdf PDF]

 

2020.10.2

ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: A genome-wide G×E interaction analysis
ALDH2の遺伝子多型が男性の飲酒量とAST/ALT比の関連を修飾する:ゲノムワイドな遺伝環境交互作用解析結果

Yoichi Sutoh, Tsuyoshi Hachiya, Yuji Suzuki, Shohei Komaki, Hideki Ohmomo, Keisuke Kakisaka, Ting Wang, Yasuhiro Takikawa, Atsushi Shimizu

[Scientific Reports][概要 icon-pdf PDF]

 

2020.2.4

A Genome-Wide Polygenic Score and the Risk of Ischemic Stroke in a Prospective Cohort: the Hisayama Study
前向きコホートにおけるゲノムワイドポリジェニックスコアと脳梗塞リスク:久山町研究

Tsuyoshi Hachiya, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Yoshihiko Furuta, Takanari Kitazono, Atsushi Shimizu, Toshiharu Ninomiya

[Stroke][プレスリリース icon-pdf PDF]

 

2020.1.12

Epigenome-wide association study identifies a novel DNA methylation in patients with severe aortic valve stenosis
大動脈弁狭窄症における新規DNAメチル化マーカーの探索

Takahito Nasu, Mamoru Satoh, Hideki Ohmomo, Yuh Shiwa, Shohei Komaki, Kanako Ono, Atsushi Shimizu, Satoru Taguchi, Yuji Takahashi, Takuya Osaki, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki

[Circulation: Genomic and Precision Medicine][概要 icon-pdf PDF]

 

2020.1.11

Study profile of The Tohoku Medical Megabank Community-Based Cohort Study
東北メディカル・メガバンク計画地域住民コホート調査の研究プロファイル

Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

[Journal of Epidemiology][概要 icon-pdf PDF]

 

2019.5.25

The value of a cystatin C-based estimated glomerular filtration rate for cardiovascular assessment in a general Japanese population: Results from the Iwate Tohoku Medical Megabank Project
東北メディカル・メガバンク計画における日本の一般住民を対象としたシスタチンCに基づく推定糸球体ろ過量を用いた心血管リスク評価の有用性

Takuya Osaki, Mamoru Satoh, Fumitaka Tanaka, Kozo Tanno, Yuji Takahashi, Takahito Nasu, Kiyomi Sakata, Yoshihiro Morino, Kenji Sobue, and Makoto Sasaki

[Journal of Epidemiology][概要 icon-pdf PDF]

 

2019.4.12

Association between high-sensitivity cardiac troponin T and future cardiovascular incidence in a general Japanese population: Results from the Tohoku Medical Megabank Project
日本の一般住民での高感度心筋トロポニンTと将来の心血管疾患発症の関連
〜東北メディカル・メガバンク計画からの報告〜

Yuji Takahashi, Mamoru Sato, Hideki Ohmomo, Fumitaka Tanaka, Takuya Osaki, Kozo Tanno, Takahito Nasu, Kiyomi Sakata, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki

[Biomarkers][概要 icon-pdf PDF]

 

2018.9.21

Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3’-BCL11B gene desert locus
食塩摂取量と交互作用し、血圧に影響を及ぼす遺伝的多型を全ゲノム関連解析によりBCL11B 遺伝子3’ 末端側の遺伝子砂漠領域に新たに同定

Tsuyoshi Hachiya, Akira Narita, Hideki Ohmomo, Yoichi Sutoh, Shohei Komaki, Kozo Tanno, Mamoru Satoh, Kiyomi Sakata, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Masayuki Yamamoto, Makoto Sasaki, Atsushi Hozawa and Atsushi Shimizu

[Scientific Reports][概要 icon-pdf PDF]

 

2018.9.5

A comparison of genome cohort participants’ genetic knowledge and preferences to receive genetic results before and after a genetics workshop
ゲノムコホート参加者に対する遺伝に関する講習会前後の遺伝学的知識ならびに遺伝学的検査結果回付への需要の比較

Kayono Yamamoto, Atsushi Shimizu, Fumie Aizawa, Hiroshi Kawame, Tomoharu Tokutomi and Akimune Fukushima

[Journal of Human Genetics][概要 icon-pdf PDF]

 

2018.3.29

iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation
iMETHYL:ヒトDNAメチル化情報、遺伝子発現情報、ゲノム多型情報からなる統合データベース

Shohei Komaki, YuhShiwa, Ryohei Furukawa, Tsuyoshi Hachiya, Hideki, Ohmomo, Ryo Otomo, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Makoto Sasaki and Atsushi Shimizu

[Human Genome Variation][概要 icon-pdf PDF]

 

2017.11.23

Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6–TMC8 and SIX3–SIX2 loci associated with HbA1c
日本人集団の全ゲノムメタ解析がHbA1cと関連するTMC6–TMC8 及び SIX3–SIX2座位の新規多型を同定

Tsuyoshi Hachiya, Shohei Komaki, Yutaka Hasegawa, Hideki Ohmomo, Kozo Tanno, Atsushi Hozawa, Gen Tamiya, Masayuki Yamamoto, Kuniaki Ogasawara, Motoyuki Nakamura, Jiro Hitomi, Yasushi Ishigaki, Makoto Sasaki and Atsushi Shimizu

[Scientific Reports][概要 icon-pdf PDF]

 

2017.10.12

An epigenome-wide association study based on cell type-specific whole-genome bisulfite sequencing: Screening for DNA methylation signatures associated with bone mass
骨量と相関する細胞種特異的DNAメチル化パターンの網羅的スクリーニング

Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Ryohei Furukawa, Yuh Shiwa, Mamoru Satoh, Ryujin Endo, Minoru Doita, Makoto Sasaki, and Atsushi Shimizu

[Integrative Molecular Medicine][概要 icon-pdf PDF]

 

2017.8.10

Population-based biobank participants’ preferences for receiving genetic test results
住民バイオバンク参加者の遺伝学的検査結果回付への需要

Kayono Yamamoto, Tsuyoshi Hachiya, Akimune Fukushima, Naoki Nakaya, Akira Okayama, Kozo Tanno, Fumie Aizawa, Tomoharu Tokutomi, Atsushi Hozawa and Atsushi Shimizu

[Journal of Human Genetics][概要 icon-pdf PDF]

 

2017.7.14

f-treeGC: A questionnaire-based family tree-creation software for genetic counseling and genome cohort studies
f-treeGC:遺伝カウンセリングやゲノムコホート研究に有用な問診票ベースの医療用家系図自動作成ソフトの開発

Tomoharu Tokutomi, Akimune Fukushima, Kayono Yamamoto, Yasushi Bansho, Tsuyoshi Hachiya, and Atsushi Shimizu

[BMC Medical Genetics][概要 icon-pdf PDF]

 

2017.4.21

Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies
全ゲノム規模の個人毎のDNAメチル化部位の変動部位の同定はエピゲノム関連解析の有効性を改善できる

Tsuyoshi Hachiya, Ryohei Furukawa, Yuh Shiwa, Hideki Ohmomo, Kanako Ono, Fumiki Katsuoka, Masao Nagasaki, Jun Yasuda, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Kozo Tanno, Mamoru Satoh, Ryujin Endo, Makoto Sasaki, Kiyomi Sakata, Seiichiro Kobayashi, Kuniaki Ogasawara, Jiro Hitomi, Kenji Sobue and Atsushi Shimizu

[Genomic Medicine][プレスリリース icon-pdf PDF]

 

2017.1.19

Genetic Predisposition to Ischemic Stroke:A Polygenic Risk Score
脳梗塞の遺伝的体質;多遺伝子リスク評価

Tsuyoshi Hachiya; Yoichiro Kamatani, Atsushi Takahashi, Jun Hata, Ryohei Furukawa, Yuh Shiwa, Taiki Yamaji, Megumi Hara, Kozo Tanno, Hideki Ohmomo, Kanako Ono; Naoyuki Takashima, Koichi Matsuda, Kenji Wakai, Norie Sawada, Motoki Iwasaki, Kazumasa Yamagishi, Tetsuro Ago, Toshiharu Ninomiya, Akimune Fukushima, Atsushi Hozawa, Naoko Minegishi, Mamoru Satoh, Ryujin Endo, Makoto Sasaki, Kiyomi Sakata, Seiichiro Kobayashi, Kuniaki Ogasawara, Motoyuki Nakamura, Jiro Hitomi, Yoshikuni Kita, Keitaro Tanaka, Hiroyasu Iso, Takanari Kitazono, Michiaki Kubo, Hideo Tanaka, Shoichiro Tsugane, Yutaka Kiyohara, Masayuki Yamamoto, Kenji Sobue, Atsushi Shimizu

[Stroke][プレスリリース icon-pdf PDF]

 

2016.5.19

Intraindividual dynamics of transcriptome and genome-wide stability of DNA methylation
個人内トランスクリプトームのダイナミクスとDNAメチル化のゲノムワイドな安定性

Ryohei Furukawa, Tsuyoshi Hachiya, Hideki Ohmomo, Yuh Shiwa, Kanako Ono, Sadafumi Suzuki, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Atsushi Shimizu

[Scientific Reports][概要 icon-pdf PDF]

 

2016.4.14

3層オミックス参照パネル公開 ~生活習慣病・がん・うつなどの予防や治療に貢献可能~

生体情報解析部門の清水教授らは東北大学東北メディカル・メガバンク機構との共同で、エピゲノム(遺伝子修飾情報)の一つである全DNAメチル化情報の100人規模の高精度な解析に初めて成功し、その情報をゲノム(遺伝子情報)・トランスクリプトーム(遺伝子転写情報)と併せて3層のオミックス(網羅的生体分子情報)参照パネルとして公開しました。
DNAメチル化は生命活動に必要な仕組みの一つですが、様々な環境要因によって異常が生じ、生活習慣病・がん・うつなどの発症に関連することが明らかとなりつつあります。今回の参照パネルを活用することで、これらの疾患の誘因となる個人個人の遺伝子修飾と環境要因との関係をさらに明らかにし、新たな予防・診断・治療法の研究開発の促進につながることが期待できます。

[プレスリリース icon-pdf PDF]
[検索サイト http://imethyl.iwate-megabank.org/]

 

2016.1.22

Adjustment of cell-type composition minimizes systematic bias in blood DNA methylation profiles derived by DNA collection protocols
国内コホート・バイオバンクの生体試料収集プロトコールの違いによるDNAメチル化状態の差の補正手法の開発

Yuh Shiwa, Tsuyoshi Hachiya, Ryohei Furukawa, Hideki Ohmomo, Kanako Ono, Hisaaki Kudo, Jun Hata, Atsushi Hozawa, Motoki Iwasaki, Koichi Matsuda, Naoko Minegishi, Mamoru Satoh, Kozo Tanno, Taiki Yamaji, Kenji Wakai, Jiro Hitomi, Yutaka Kiyohara, Michiaki Kubo, Hideo Tanaka, Shoichiro Tsugane, Masayuki Yamamoto, Kenji Sobue, Atsushi Shimizu

[PLOS ONE][概要 icon-pdf PDF]

 

2014.8.7

Reduction of systematic bias in transcriptome data from human peripheral blood mononuclear cells for transportation and biobanking
収集された血液のRNAを採血時の品質で保持させる前処理方法と遠隔地から解析本部までの検体輸送方法の検討

Hideki Ohmomo, Tsuyoshi Hachiya, Yu Shiwa, Ryohei Furukawa, Kanako Ono, Shigeki Ito, Yoji Ishida, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Atsushi Shimizu
[PLOS ONE][概要 icon-pdf PDF]