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2024.3.21 The health history of first-degree relatives’ dyslipidemia can affect preferences and intentions following the return of genomic results for monogenic familial hypercholesterolemia Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Kayono Yamamoto, Yasushi Ishigaki, Hiroshi Kawame, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Akira Uruno, Kichiya Suzuki, Kozo Tanno, Hideki Ohmomo, Atsushi Shimizu, Masayuki Yamamoto and Makoto Sasaki |
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2023.12.28 Stakeholder perception of the implementation of genetic risk testing for twelve multifactorial diseases Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Fuji Nagami, Yuko Minoura and Makoto Sasaki |
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2023.9.21 Association between vascular endothelial dysfunction and stroke incidence in the general Japanese population: results from the Tohoku medical megabank community-based cohort study Harutomo Numazaki, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Koichi Asahi, Hideki Ohmomo, Atsushi Shimizu, Shinichi Omama, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki [International Journal of Cardiology Cardiovascular Risk and Prevention][概要 |
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2023.3.28 Japanese Translation and Validation of Genomic Knowledge Measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK) Akiko Yoshida, Tomoharu Tokutomi, Akimune Fukushima, Robert Chapman,Fatos Selita, Yulia Kovas, Makoto Sasaki |
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2023.2.17 Association between the extent of house collapse and urine sodium-to-potassium ratio of victims affected by the 2011 Great East Japan Earthquake and Tsunami: a cross-sectional study Takahiro Mikami, Kozo Tanno, Ryohei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Koichi Asahi, Fumitaka Tanaka, Shinichi Omama, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Atsushi Hozawa, Jiro Hitomi, Kiyomi Sakata, Makoto Sasaki [Hypertension Research][概要 |
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2022.11.1 Association between Plasma Xanthine Oxidoreductase Activity and the Renal Function in a General Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study Satoru Taguchi, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Fumitaka Tanaka, Koichi Asahi, Hideki Ohmomo, Hiroto Kikuchi, Takamasa Kobayashi, Yoshihiro Morino, Atsushi Shimizu, Kenji Sobue, Makoto Sasaki |
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2022.9.28 Association between high-sensitivity cardiac troponin T levels and incident stroke in the elderly Japanese population: Results from the Tohoku Medical Megabank Community-based Cohort Study Takamasa Kobayashi, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Koichi Asahi, Hideki Ohmomo, Atsushi Shimizu, Shinichi Omama, Hiroto Kikuchi , Satoru Taguchi, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki |
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2022.6.9 Evaluation of short-term epigenetic age fluctuation Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Shiori Minabe, Akira Takashima, Kozo Tanno, Makoto Sasaki ,and Atsushi Shimizu [Clinical Epigenetics][概要 |
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2022.5.20 Association between total type I collagen N-terminal propeptide and coronary artery disease risk score in the general Japanese population Hiroto Kikuchi, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Koichi Asahi, Hideki Ohmomo, Takamasa Kobayashi, Satoru Taguchi, Yoshihiro Morino, Atsushi Shimizu, Kenji Sobue, Makoto Sasaki, [International Journal of Cardiology Heart & Vasculature][概要 |
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2022.4.5 Association between Social Isolation and Total Mortality after the Great East Japan Earthquake in Iwate Prefecture: Findings from the TMM CommCohort Study Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Kotaro Otsuka, Ryohei Sasaki, Nobuyuki Takanashi, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki [International Journal of Environmental Research and Public Health] |
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2021.12.22 Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka‑Yamasaki, Kozo Tanno, Makoto Sasaki ,and Atsushi Shimizu [Clinical Epigenetics][概要 |
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2021.12.8 Low MICA gene expression confers an increased risk of Graves’ disease: a Mendelian randomization study Yoichi Sutoh, Shohei Komaki, Taiki Yamaji, Shiori Suzuki, Ryoko Katagiri, Norie Sawada, Kanako Ono, Hideki Ohmomo, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Akira Takashima, So Umekage, Motoki Iwasaki, and Atsushi Shimizu |
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2021.5.15 Association between the social isolation and depressive symptoms after the Great East Japan Earthquake: Findings from the baseline survey of the TMM CommCohort Study Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Eri Takusari,Kotaro Otsuka, Hiroaki Tomita, Ryohei Sasaki, Nobuyuki Takanashi, Takahiro Mikami, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yasuyuki Taki, Atsushi Shimizu, Jiro Hitomi, Mamoru Satoh, Makoto Sasaki [BMC Public Health][概要 |
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2021.2.16 Plasma xanthine oxidoreductase activity is associated with a high risk of cardiovascular disease in a general Japanese population Yuka Kotozaki, Mamoru Satoh, Kozo Tanno, Hideki Ohmomo, Ryo Otomo, Fumitaka Tanaka, Takahito Nasu, Satoru Taguchi, Hiroto Kikuchi, Takamasa Kobayashi, Atsushi Shimizu, Kiyomi Sakata, Jiro Hitomi, Kenji Sobue, Makoto Sasaki [International Journal of Environmental Research and Public Health] |
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2020.12.18 Evaluation of clinical formalin-fixed paraffin-embedded tissue quality for targeted-bisulfite sequencing Hideki Ohmomo, Shohei Komaki, Kanako Ono, Yoichi Sutoh, Tsuyoshi Hachiya, Eri Arai, Hiroyuki Fujimoto, Teruhiko Yoshida, Yae Kanai, Makoto Sasaki, Atsushi Shimizu [Pathology International][概要 |
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2020.12.13 A genome-wide association study for highly sensitive cardiac troponin T levels identified a novel genetic variation near a RBAK-ZNF890P locus in the Japanese general population Takahito Nasu, Mamoru Satoh, Tsuyoshi Hachiya, Yoichi Sutoh, Hideki Ohmomo, Sho Hitom, Satoru Taguchi, Hiroto Kikuchi, Takamasa Kobayashi, Yuji Takahashi, Takuya Osaki, Yoshihiro Morino, Atsushi Shimizu, Kenji Sobue, Makoto Sasaki |
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2020.10.2 ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: A genome-wide G×E interaction analysis Yoichi Sutoh, Tsuyoshi Hachiya, Yuji Suzuki, Shohei Komaki, Hideki Ohmomo, Keisuke Kakisaka, Ting Wang, Yasuhiro Takikawa, Atsushi Shimizu [Scientific Reports][概要 |
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2020.2.4 A Genome-Wide Polygenic Score and the Risk of Ischemic Stroke in a Prospective Cohort: the Hisayama Study Tsuyoshi Hachiya, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Yoshihiko Furuta, Takanari Kitazono, Atsushi Shimizu, Toshiharu Ninomiya |
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2020.1.12 Epigenome-wide association study identifies a novel DNA methylation in patients with severe aortic valve stenosis Takahito Nasu, Mamoru Satoh, Hideki Ohmomo, Yuh Shiwa, Shohei Komaki, Kanako Ono, Atsushi Shimizu, Satoru Taguchi, Yuji Takahashi, Takuya Osaki, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki |
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2020.1.11 Study profile of The Tohoku Medical Megabank Community-Based Cohort Study Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto
[Journal of Epidemiology][概要 |
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2019.5.25 The value of a cystatin C-based estimated glomerular filtration rate for cardiovascular assessment in a general Japanese population: Results from the Iwate Tohoku Medical Megabank Project Takuya Osaki, Mamoru Satoh, Fumitaka Tanaka, Kozo Tanno, Yuji Takahashi, Takahito Nasu, Kiyomi Sakata, Yoshihiro Morino, Kenji Sobue, and Makoto Sasaki
[Journal of Epidemiology][概要 |
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2019.4.12 Association between high-sensitivity cardiac troponin T and future cardiovascular incidence in a general Japanese population: Results from the Tohoku Medical Megabank Project Yuji Takahashi, Mamoru Sato, Hideki Ohmomo, Fumitaka Tanaka, Takuya Osaki, Kozo Tanno, Takahito Nasu, Kiyomi Sakata, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki
[Biomarkers][概要 |
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2018.9.21 Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3’-BCL11B gene desert locus Tsuyoshi Hachiya, Akira Narita, Hideki Ohmomo, Yoichi Sutoh, Shohei Komaki, Kozo Tanno, Mamoru Satoh, Kiyomi Sakata, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Masayuki Yamamoto, Makoto Sasaki, Atsushi Hozawa and Atsushi Shimizu
[Scientific Reports][概要 |
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2018.9.5 A comparison of genome cohort participants’ genetic knowledge and preferences to receive genetic results before and after a genetics workshop Kayono Yamamoto, Atsushi Shimizu, Fumie Aizawa, Hiroshi Kawame, Tomoharu Tokutomi and Akimune Fukushima
[Journal of Human Genetics][概要 |
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2018.3.29 iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation Shohei Komaki, YuhShiwa, Ryohei Furukawa, Tsuyoshi Hachiya, Hideki, Ohmomo, Ryo Otomo, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Makoto Sasaki and Atsushi Shimizu
[Human Genome Variation][概要 |
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2017.11.23 Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6–TMC8 and SIX3–SIX2 loci associated with HbA1c Tsuyoshi Hachiya, Shohei Komaki, Yutaka Hasegawa, Hideki Ohmomo, Kozo Tanno, Atsushi Hozawa, Gen Tamiya, Masayuki Yamamoto, Kuniaki Ogasawara, Motoyuki Nakamura, Jiro Hitomi, Yasushi Ishigaki, Makoto Sasaki and Atsushi Shimizu
[Scientific Reports][概要 |
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2017.10.12 An epigenome-wide association study based on cell type-specific whole-genome bisulfite sequencing: Screening for DNA methylation signatures associated with bone mass Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Ryohei Furukawa, Yuh Shiwa, Mamoru Satoh, Ryujin Endo, Minoru Doita, Makoto Sasaki, and Atsushi Shimizu |
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2017.8.10 Population-based biobank participants’ preferences for receiving genetic test results Kayono Yamamoto, Tsuyoshi Hachiya, Akimune Fukushima, Naoki Nakaya, Akira Okayama, Kozo Tanno, Fumie Aizawa, Tomoharu Tokutomi, Atsushi Hozawa and Atsushi Shimizu
[Journal of Human Genetics][概要 |
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2017.7.14 f-treeGC: A questionnaire-based family tree-creation software for genetic counseling and genome cohort studies Tomoharu Tokutomi, Akimune Fukushima, Kayono Yamamoto, Yasushi Bansho, Tsuyoshi Hachiya, and Atsushi Shimizu
[BMC Medical Genetics][概要 |
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2017.4.21 Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies Tsuyoshi Hachiya, Ryohei Furukawa, Yuh Shiwa, Hideki Ohmomo, Kanako Ono, Fumiki Katsuoka, Masao Nagasaki, Jun Yasuda, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Kozo Tanno, Mamoru Satoh, Ryujin Endo, Makoto Sasaki, Kiyomi Sakata, Seiichiro Kobayashi, Kuniaki Ogasawara, Jiro Hitomi, Kenji Sobue and Atsushi Shimizu
[Genomic Medicine][プレスリリース |
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2017.1.19 Genetic Predisposition to Ischemic Stroke：A Polygenic Risk Score Tsuyoshi Hachiya; Yoichiro Kamatani, Atsushi Takahashi, Jun Hata, Ryohei Furukawa, Yuh Shiwa, Taiki Yamaji, Megumi Hara, Kozo Tanno, Hideki Ohmomo, Kanako Ono; Naoyuki Takashima, Koichi Matsuda, Kenji Wakai, Norie Sawada, Motoki Iwasaki, Kazumasa Yamagishi, Tetsuro Ago, Toshiharu Ninomiya, Akimune Fukushima, Atsushi Hozawa, Naoko Minegishi, Mamoru Satoh, Ryujin Endo, Makoto Sasaki, Kiyomi Sakata, Seiichiro Kobayashi, Kuniaki Ogasawara, Motoyuki Nakamura, Jiro Hitomi, Yoshikuni Kita, Keitaro Tanaka, Hiroyasu Iso, Takanari Kitazono, Michiaki Kubo, Hideo Tanaka, Shoichiro Tsugane, Yutaka Kiyohara, Masayuki Yamamoto, Kenji Sobue, Atsushi Shimizu |
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2016.5.19 Intraindividual dynamics of transcriptome and genome-wide stability of DNA methylation Ryohei Furukawa, Tsuyoshi Hachiya, Hideki Ohmomo, Yuh Shiwa, Kanako Ono, Sadafumi Suzuki, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Atsushi Shimizu
[Scientific Reports][概要 |
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2016.4.14 ３層オミックス参照パネル公開 ～生活習慣病・がん・うつなどの予防や治療に貢献可能～ 生体情報解析部門の清水教授らは東北大学東北メディカル・メガバンク機構との共同で、エピゲノム（遺伝子修飾情報）の一つである全ＤＮＡメチル化情報の100人規模の高精度な解析に初めて成功し、その情報をゲノム(遺伝子情報)・トランスクリプトーム（遺伝子転写情報）と併せて３層のオミックス（網羅的生体分子情報）参照パネルとして公開しました。 |
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[プレスリリース |
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2016.1.22 Adjustment of cell-type composition minimizes systematic bias in blood DNA methylation profiles derived by DNA collection protocols Yuh Shiwa, Tsuyoshi Hachiya, Ryohei Furukawa, Hideki Ohmomo, Kanako Ono, Hisaaki Kudo, Jun Hata, Atsushi Hozawa, Motoki Iwasaki, Koichi Matsuda, Naoko Minegishi, Mamoru Satoh, Kozo Tanno, Taiki Yamaji, Kenji Wakai, Jiro Hitomi, Yutaka Kiyohara, Michiaki Kubo, Hideo Tanaka, Shoichiro Tsugane, Masayuki Yamamoto, Kenji Sobue, Atsushi Shimizu |
[PLOS ONE][概要  PDF] |
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2014.8.7 Reduction of systematic bias in transcriptome data from human peripheral blood mononuclear cells for transportation and biobanking |
| Hideki Ohmomo, Tsuyoshi Hachiya, Yu Shiwa, Ryohei Furukawa, Kanako Ono, Shigeki Ito, Yoji Ishida, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Atsushi Shimizu |
| [PLOS ONE][概要 PDF] |
